Buffalo Bills at San Francisco 49ers Betting Preview

Bills @ 49ers

Buffalo Bills at San Francisco 49ers Betting Preview

The 8-3 Buffalo Bills knew they’d be heading across the country for the second time in three weeks but they didn’t know they’d go right back to Arizona instead of California. They play the San Francisco 49ers (5-6) Monday night but since local authorities won’t allow the 49ers to practice or play at home, this game will be at the home of the Arizona Cardinals.  This Monday Night game kicks off at 8:15 ET from State Farm Stadium in Glendale, Ari. and will be televised on ESPN.

These teams have only met 12 times and the series is tied 6-6. The last meeting was in 2016 with the Bills winning at home 45-16. San Francisco won at home in 2012 and on the road in 2008.

Buffalo Bills Betting Outlook: Take Offense on Road

In betting with us at a1pph.com, the Bills are 6-5 ATS and the over is 7-3-1 in their 11 games.  Buffalo lost at Arizona 32-30 on November 15 with that insane DeAndre Hopkins hail mary catch beating them at the buzzer. They have averaged 32 ppg in their last three home games but only 21.3 ppg in the last three road games.

Quarterback Josh Allen completed just 18 passes for 157 yards against the Charges last week. He has 3,028 passing yards on the season with 22 touchdowns and eight interceptions.

Devin Singletary ran for 82 yards against the Chargers while Zack Moss added 59. Allen ran for 32 yards and had a touchdown to go with his passing TD. Singletary has 483 yards and two touchdowns on the season while Moss has 283 yards and three scores.

Wideout Stefon Diggs has 80 catches on the season for 945 yards with four touchdowns. Cole Beasley has 57 catches for 687 yards and three scores and Gabriel Davis had last weeks touchdown.

San Francisco 49ers Betting Outlook: Go After Allen

Betting with us at a1pph.com the 49ers are 5-6 ATS this season and the under is 6-5 in their 11 games. The Niners got back into the playoff race Sunday with a 23-20 road upset of the LA Rams. They had lost three in a row, allowing an average of 33 ppg in those losses to the Saints, packers and Seahawks.

Quarterback Nick Mullens threw for 252 yards and one interception against the Rams. He has 1,642 yards while filling in for Jimmy Garoppolo. Mullens has six touchdowns with seven interceptions.

Raheem Mostert had the 49ers only offensive touchdown as he tallied 43 yards while Jeff Wilson Jr. had 40 yards.  Mostert has a team-leading 346 yards on the season while Jerrick McKinnon leads the team with five touchdowns.

With Brandon Aiyuk (COVID) out, wideout Deebo Samuel had a big day with 11 catches for 133 yards. Tight end George Kittle missed another game with an injury but still leads the team with 37 catches and 474 yards.

Buffalo Bills at San Francisco 49ers Betting Line

Head to our favorite pay per head bookie site at A1pph where the Bills are favored by 2.5 points with a total of 48 points.

Betting Analysis

The 49ers defense has been outstanding ranking fourth in the NFL in passing yards and sixth in total yards. The Bills offense is seventh in the league in passing and 10th in scoring but they haven’t played well on the road where they are 2-3 ATS in the last five. If the line can keep Allen upright, the Bills should be able to take care of business and move a step closer to an AFC East title.

Free Pick By Gameadvisers: Bills -2.5 (-110)